Brett Clementz, a professor of psychology in the Franklin College of Arts and Sciences, was awarded $74,000 by the National Institutes of Health to study psychotic symptoms in individuals with bipolar disorder. Most biomedical research on bipolar disorder has ignored the fact that some bipolar patients present psychotic symptoms while others do not. This project will collect a comprehensive battery of biological, neurophysiologic, cognitive and clinical measures from a large sample of bipolar disorder patients to determine whether those with psychosis and those without psychosis represent a difference in degree or a difference in kind. This is a multi-site project featuring partners from Harvard, Yale and UT Southwestern.